A randomized, double-blind, placebo- and active-controlled, half-head study to evaluate the effects of platelet-rich plasma on alopecia areata

Summary Background Alopecia areata (AA) is a common autoimmune condition, causing inflammation-induced hair loss. This disease has very limited treatment possibilities, and no treatment is either curative or preventive. Platelet-rich plasma (PRP) has emerged as a new treatment modality in dermatology, and preliminary evidence has suggested that it might have a beneficial role in hair

Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn’s disease: results from a multicenter phase I/IIa clinical trial

Background COPD is a devastating disease affecting millions worldwide. As disease pathogenesis includes both chronic pulmonary and systemic inflammation, antiinflammatory effects of systemically administered mesenchymal stem cells (MSCs) may decrease inflammation, resulting in improved lung function and quality of life. The goal of this study was to assess safety and to perform an initial evaluation

Comparison Between Hyaluronic Acid and Platelet-Rich Plasma, Intra-articular Infiltration in the Treatment of Gonarthrosis

A good recent article from the American Journal of Sports Medicine. It matches Surecell clinical observations. The key points are that the benefit of hyaluronic acid is very transient and does not work for severe OA, while PRP benefit is sustained and nearly as good in severe as mild OA. Study published in The American

Adipose-Derived Mesenchymal Stem Cells: Biology and Potential Applications

Adipose tissue is derived from the mesoderm during embryonic development and is present in every mammalian species, located throughout the body. Adipose tissue serves as an endocrine organ, functioning to maintain energy metabolism through the storage of lipids. While two types of adipose tissue exist (brown and white), white adipose yields the commonly studied adipose-derived

Tendon Regeneration and Repair with Adipose Derived Stem Cells

Tendon, the crucial element of the musculoskeletal system, when damaged, never restores the biological and biomechanical properties completely. Recently, tissue engineering and regenerative medicine have enabled the differentiation of postnatal somatic stem cells or mesenchymal stem cells (MSCs) to different cell lineages and tissues including tendon. In addition, the MSCs, mainly bone marrow derived stem

Autologous Adipose Tissue-Derived Stem Cells Induce Persistent Bone-Like Tissue in Osteonecrotic Femoral Heads

Study published in the Pain Physician Journal, January/February 2012 issue, to determine if treatment with adipose tissue-derived stem cells and platelet-rich plasma leads to the regeneration of meullary bone-like tissue and long-term reduction of hip pain in 2 patients with femoral head osteonecrosis. These 2 cases demonstrate the presence of stustained, regenerated medullary bonelike tissue

Platelet-Rich Plasma or Hyaluronate in the Management of Osteochondral Lesions of the Talus

Randomized controlled trial with 32 patients aged 18 to 60 years, published in the American Journal of Sports medicine January 2012, to evaluate the short-term efficacy and safety of platelet-rich plasma (PRP) compared with hyaluronic acid (HA) in reducing pain and disability caused by OCLs of the ankle. Osteochondral lesions of the ankle treated with

A Novel Biological Approach to Treat Chondromalacia Patellae

Study published in May 2013 on humans treated with adipose tissue derived stem cells (ADSCs) for Chondromalacia Patellae. Patients treated were subject to pre- and post-treatment magnetic resonance imaging (MRI) scans, pre- and post-treatment subjective pain scores and physical therapy assessments measured clinical changes. One month after the injection of autologuous ADSCs, each patient’s pain

Treatment of Chronic Elbow Tendinosis With Buffered Platelet-Rich Plasma

Cohort study covering 140 patients with elbow epicondylar pain, published in the American Journal of Sports medicine November 2006, vol. 34. Treatment of patients with chronic elbow tendinosis with buffered platelet-rich plasma reduced pain significantly. The American Journal of Sports Medicine | ajs.sagepub.com | November 2006 | Volume 34 | Number 11 Read the article